Publications

Branchfield K, Nantie L, Verheyden JM, Sui P, Weinhold, MD, Sun X.  Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12; 351(6274):707-10. [Full Text] [Abstract] [PubMed]  See perspective here

Branchfield K, Li R, Lungova V, Veheyden J, McCulley D, Sun X. A Three-Dimensional Study of Alveologenesis in Mouse Lung. Dev Biol. 2015 Nov 26. [PubMed]

Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X. FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 2015 Nov 9;35(3):322-32. [PubMed]

McCulley D, Wienhold M, Sun X. The pulmonary mesenchyme directs lung development. Curr Opin Genet Dev. 2015 Jun;32:98-105. [PubMed]

Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL. Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82. [PubMed]

Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF Jr. Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction. PLoS One. 2014 Dec 1;9(12):e112997. [PubMed]

Hines EA, Sun X. Tissue crosstalk in lung development. J Cell Biochem. 2014 Sep;115(9):1469-77. [PubMed]

Pham D, Sehra S, Sun X and Kaplan MH. (2014) The transcription factor Etv5 controls T helper 17 development and allergic inflammation. J All. Clin. Imm. 134(1):204-14. [PubMed]

Hines EA, Jones MK, Verheyden JM, Harvey JF, Sun X. Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. PNAS. 2013 Nov 26;110(48):19444-9. [PubMed]

Sorkness RL, Szakaly RJ, Rosenthal LA, Sullivan R, Gern JE, Lemanske RF Jr, Sun X. Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function. Am J Respir Cell Mol Biol. 2013 Nov;49(5):808-13. [PubMed]

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr;10(2):S12-6. [PubMed]

Mehta V, Schmitz CT, Keil KP, Joshi PS, Abler LL, Lin TM, Taketo MM, Sun X, Vezina CM. Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol. 2013 Apr 15;376(2):125-35. [PubMed]

Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X. Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63. [PubMed]

Du, Y., Xu, G.F., Ding, Y.Q., Liu, Y., Sun, X. and Xu,G.L. (2013) The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. Plos One, 7(10)e47358, 1-10. [PubMed]

Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X. Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53. [PubMed]

Domyan ET, Sun X. Patterning and plasticity in development of the respiratory lineage. Dev Dyn. 2011 Mar;240(3):477-85. [PubMed]

Bochkov YA, Palmenberg AC, Lee WM, RatheSun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. (2011) Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med. 17(5):627-32. [PubMed]

Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development. 2011 Mar;138(5):971-81. [PubMed]

Zhang Z, O’Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X. The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65. [PubMed]

Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 2010 Oct;137(20):3417-26. [PubMed]

Harris-Johnson KS, Domyan ET, Vezina CM, Sun X. beta-Catenin promotes respiratory progenitor identity in mouse foregut. PNAS. 2009 Sep 22;106(38):16287-92. [PubMed]

Abler LL, Mansour SL, Sun X. Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009 Aug;238(8):1999-2013. [PubMed]

Zhang Z, Verheyden JM, Hassell JA, Sun X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr;16(4):607-13. [PubMed]

Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT., Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15;18(10):1740-54. [PubMed]

Yi L, Domyan ET, Lewandoski M, Sun X. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn. 2009 Jan;238(1):123-37. [PubMed]

Verheyden JM, Sun X. An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature. 2008 Jul 31;454(7204):638-41. [PubMed]

Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X. Dicer function is essential for lung epithelium morphogenesis. PNAS. 2006 Feb 14;103(7):2208-13. [PubMed]

Verheyden, J.M, Lewandoski, M., Deng, C.X., Harfe, B.D. and Sun, X. (2005) Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.  Development 132, 4235-4245. [PubMed]

Sun X, Mariani FV, Martin GR. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002 Aug 1;418(6897):501-8. [PubMed]

Lewandoski M, Sun X, Martin GR. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet. 2000 Dec;26(4):460-3. [PubMed]

Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE Jr, Martin GR. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet. 2000 May;25(1):83-6. [PubMed]

Minowada G, Jarvis LA, Chi CL, Neubüser A, Sun X, Hacohen N, Krasnow MA, Martin GR. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75. [PubMed]

Sun, X., Meyers, E.N., Lewandoski, M. and Martin, G.R. (1999). Targeted disruption of Fgf8 causes failure of cell migration during mouse gastrulation.  Genes Dev. 13, 1834-1846. [PubMed]

Hing, H.K., Bangalore, L., Sun, X. and Artavanis-Tsakonas, S. (1999)  Mutations in the heat shock cognate 70 protein (hsc4) modulate Notch signaling.  Eur. J. Cell Biol. 78, 690-697. [PubMed]

Matsuno, K., Go, M.J., Sun, X., Eastman, D.S., Artavanis-Tsakonas, S. (1997). Suppresser of Hairless-independent events in Notch signaling imply novel pathway elements.  Development 124, 4265-4273. [PubMed]

Sun, X. and Artavanis-Tsakonas, S. (1997). Secreted forms of DELTA and SERRATE define antagonists of NOTCH signaling in Drosophila.  Development 124, 3439-3448. [PubMed]